Investigating Field Efficacy and Safety of Conjunctival Brucella abortus S19 Vaccine in Cattle

Background: Vaccination is the most fundamental strategy in control and eradication of brucellosis. Several vaccination programs with different vaccines have been carried out many countries which brucellosis continues to be a problem livestock. One recommended against cattle live Brucella abortus S19 vaccine. The aim this study evaluate results field safety efficacy trials for conjunctival vaccine prior mass program. Methods: In study, 81 female were vaccinated reduced dose route. immune response after was investigated by suggested serological tests; namely, Rose Bengal Plate Test, Serum Agglutination Test Complement Fixation Test. Result: No adverse effect observed within scope safety. Isolation strain only milk sample lactating animals. Excluding diagnosis criteria tests, humoral animals all tests one month vaccination. Antibody levels lasted approximately 4 months conclusion, demonstrated that besides vaccine-induced antibodies, including changes administration way did not cause any significant risks target